diff --git a/sentry_sdk/integrations/openai.py b/sentry_sdk/integrations/openai.py
index 53d464c3c4..79724f389d 100644
--- a/sentry_sdk/integrations/openai.py
+++ b/sentry_sdk/integrations/openai.py
@@ -18,7 +18,7 @@
     safe_serialize,
 )
 
-from typing import TYPE_CHECKING
+from typing import TYPE_CHECKING, Dict
 
 if TYPE_CHECKING:
     from typing import Any, Iterable, List, Optional, Callable, AsyncIterator, Iterator
@@ -177,6 +177,68 @@ def _calculate_token_usage(
     )
 
 
+def _convert_message_parts(messages: "List[Dict[str, Any]]") -> "List[Dict[str, Any]]":
+    """
+    Convert the message parts from OpenAI format to the `gen_ai.request.messages` format.
+    e.g:
+    {
+        "role": "user",
+        "content": [
+            {
+                "text": "How many ponies do you see in the image?",
+                "type": "text"
+            },
+            {
+                "type": "image_url",
+                "image_url": {
+                    "url": "data:image/jpeg;base64,...",
+                    "detail": "high"
+                }
+            }
+        ]
+    }
+    becomes:
+    {
+        "role": "user",
+        "content": [
+            {
+                "text": "How many ponies do you see in the image?",
+                "type": "text"
+            },
+            {
+                "type": "blob",
+                "modality": "image",
+                "mime_type": "image/jpeg",
+                "content": "data:image/jpeg;base64,..."
+            }
+        ]
+    }
+    """
+
+    def _map_item(item: "Dict[str, Any]") -> "Dict[str, Any]":
+        if item.get("type") == "image_url":
+            image_url = item.get("image_url") or {}
+            if image_url.get("url", "").startswith("data:"):
+                return {
+                    "type": "blob",
+                    "modality": "image",
+                    "mime_type": item["image_url"]["url"].split(";base64,")[0],
+                    "content": item["image_url"]["url"].split(";base64,")[1],
+                }
+            else:
+                return {
+                    "type": "uri",
+                    "uri": item["image_url"]["url"],
+                }
+        return item
+
+    for message in messages:
+        content = message.get("content")
+        if isinstance(content, list):
+            message["content"] = [_map_item(item) for item in content]
+    return messages
+
+
 def _set_input_data(
     span: "Span",
     kwargs: "dict[str, Any]",
@@ -198,6 +260,8 @@ def _set_input_data(
         and integration.include_prompts
     ):
         normalized_messages = normalize_message_roles(messages)
+        normalized_messages = _convert_message_parts(normalized_messages)
+
         scope = sentry_sdk.get_current_scope()
         messages_data = truncate_and_annotate_messages(normalized_messages, span, scope)
         if messages_data is not None:
diff --git a/tests/integrations/openai/test_openai.py b/tests/integrations/openai/test_openai.py
index 814289c887..f4f616fad3 100644
--- a/tests/integrations/openai/test_openai.py
+++ b/tests/integrations/openai/test_openai.py
@@ -43,6 +43,7 @@
 from sentry_sdk.integrations.openai import (
     OpenAIIntegration,
     _calculate_token_usage,
+    _convert_message_parts,
 )
 from sentry_sdk.ai.utils import MAX_GEN_AI_MESSAGE_BYTES
 from sentry_sdk._types import AnnotatedValue
@@ -1509,6 +1510,77 @@ def test_openai_message_role_mapping(sentry_init, capture_events):
     assert "ai" not in roles
 
 
+def test_convert_message_parts_image_url_to_blob():
+    """Test that OpenAI image_url message parts are correctly converted to blob format"""
+    messages = [
+        {
+            "role": "user",
+            "content": [
+                {
+                    "text": "How many ponies do you see in the image?",
+                    "type": "text",
+                },
+                {
+                    "type": "image_url",
+                    "image_url": {
+                        "url": "data:image/jpeg;base64,/9j/4AAQSkZJRg==",
+                        "detail": "high",
+                    },
+                },
+            ],
+        }
+    ]
+
+    converted = _convert_message_parts(messages)
+
+    assert len(converted) == 1
+    assert converted[0]["role"] == "user"
+    assert isinstance(converted[0]["content"], list)
+    assert len(converted[0]["content"]) == 2
+
+    # First item (text) should remain unchanged
+    assert converted[0]["content"][0] == {
+        "text": "How many ponies do you see in the image?",
+        "type": "text",
+    }
+
+    # Second item (image_url) should be converted to blob format
+    blob_item = converted[0]["content"][1]
+    assert blob_item["type"] == "blob"
+    assert blob_item["modality"] == "image"
+    assert blob_item["mime_type"] == "data:image/jpeg"
+    assert blob_item["content"] == "/9j/4AAQSkZJRg=="
+    # Verify the original image_url structure is replaced
+    assert "image_url" not in blob_item
+
+
+def test_convert_message_parts_image_url_to_uri():
+    """Test that OpenAI image_url with non-data URLs are converted to uri format"""
+    messages = [
+        {
+            "role": "user",
+            "content": [
+                {
+                    "type": "image_url",
+                    "image_url": {
+                        "url": "https://example.com/image.jpg",
+                        "detail": "low",
+                    },
+                },
+            ],
+        }
+    ]
+
+    converted = _convert_message_parts(messages)
+
+    assert len(converted) == 1
+    uri_item = converted[0]["content"][0]
+    assert uri_item["type"] == "uri"
+    assert uri_item["uri"] == "https://example.com/image.jpg"
+    # Verify the original image_url structure is replaced
+    assert "image_url" not in uri_item
+
+
 def test_openai_message_truncation(sentry_init, capture_events):
     """Test that large messages are truncated properly in OpenAI integration."""
     sentry_init(