diff --git a/.evergreen/functions.yml b/.evergreen/functions.yml
index c1f32d78bc7..c04aaf8e973 100644
--- a/.evergreen/functions.yml
+++ b/.evergreen/functions.yml
@@ -40,7 +40,7 @@ variables:
     EVERGREEN_VERSION_ID: ${version_id}
     EVERGREEN_WORKDIR: ${workdir}
     EVERGREEN_CREATED_AT: ${created_at}
-    NODE_JS_VERSION: '22.15.1'
+    NODE_JS_VERSION: '22.21.1'
     NPM_VERSION: '10.2.4'
     # secrets
     HADRON_METRICS_INTERCOM_APP_ID: ${metrics_intercom_app_id}
diff --git a/.github/workflows/authors-and-third-party-notices.yaml b/.github/workflows/authors-and-third-party-notices.yaml
index 603f84138c3..3da46af2436 100644
--- a/.github/workflows/authors-and-third-party-notices.yaml
+++ b/.github/workflows/authors-and-third-party-notices.yaml
@@ -40,7 +40,7 @@ jobs:
 
       - uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Install npm@10.2.4
diff --git a/.github/workflows/bump-packages.yaml b/.github/workflows/bump-packages.yaml
index 6d04ddaad75..dd2aa4d6ee1 100644
--- a/.github/workflows/bump-packages.yaml
+++ b/.github/workflows/bump-packages.yaml
@@ -31,7 +31,7 @@ jobs:
 
       - uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Install npm@10.2.4
diff --git a/.github/workflows/publish-compass.yaml b/.github/workflows/publish-compass.yaml
index a5d034d7f44..bf6d835b170 100644
--- a/.github/workflows/publish-compass.yaml
+++ b/.github/workflows/publish-compass.yaml
@@ -25,7 +25,7 @@ jobs:
       - name: Setup Node.js Environment
         uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Install npm@10.2.4
diff --git a/.github/workflows/publish-packages.yaml b/.github/workflows/publish-packages.yaml
index e7961cf3981..dc8b9ded9db 100644
--- a/.github/workflows/publish-packages.yaml
+++ b/.github/workflows/publish-packages.yaml
@@ -37,7 +37,7 @@ jobs:
       - name: 'Use Node.js'
         uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
 
       - name: Install npm@10.2.4
         run: npm install -g npm@10.2.4
diff --git a/.github/workflows/start-beta.yml b/.github/workflows/start-beta.yml
index b88f5a3145a..7ba4b36352a 100644
--- a/.github/workflows/start-beta.yml
+++ b/.github/workflows/start-beta.yml
@@ -33,7 +33,7 @@ jobs:
 
       - uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Install npm@10.2.4
diff --git a/.github/workflows/start-ga.yaml b/.github/workflows/start-ga.yaml
index dc5d0c74cf1..cdc122104b9 100644
--- a/.github/workflows/start-ga.yaml
+++ b/.github/workflows/start-ga.yaml
@@ -33,7 +33,7 @@ jobs:
 
       - uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Install npm@10.2.4
diff --git a/.github/workflows/test-installers.yml b/.github/workflows/test-installers.yml
index b62f6576800..f265fe11194 100644
--- a/.github/workflows/test-installers.yml
+++ b/.github/workflows/test-installers.yml
@@ -189,7 +189,7 @@ jobs:
       - name: Setup Node.js
         uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Run post-checkout command
diff --git a/.github/workflows/update-dependencies.yaml b/.github/workflows/update-dependencies.yaml
index 9d791093f30..e72885fd9fd 100644
--- a/.github/workflows/update-dependencies.yaml
+++ b/.github/workflows/update-dependencies.yaml
@@ -66,7 +66,7 @@ jobs:
 
       - uses: actions/setup-node@v4
         with:
-          node-version: 22.15.1
+          node-version: 22.21.1
           cache: 'npm'
 
       - name: Install npm@10.2.4
diff --git a/.tool-versions b/.tool-versions
index fa62860b819..98c84e7ee29 100644
--- a/.tool-versions
+++ b/.tool-versions
@@ -3,4 +3,4 @@
 
 # This Node.js version matches the one required in
 # the "engines" in the package.json.
-nodejs 22.17.1
+nodejs 22.21.1
diff --git a/configs/mocha-config-compass/index.js b/configs/mocha-config-compass/index.js
index 6a755d1b524..dcde079561b 100644
--- a/configs/mocha-config-compass/index.js
+++ b/configs/mocha-config-compass/index.js
@@ -12,4 +12,15 @@ module.exports = {
     path.resolve(__dirname, 'register', 'resolve-from-source-register.js'),
     path.resolve(__dirname, 'register', 'node-env-register.js'),
   ],
+  'node-option': [
+    // TODO(COMPASS-10162): starting with Node.js 22.15+ there is an issue
+    // seemingly caused by Node.js still parsing files with .ts extension even
+    // if experimental-strip-types option is not enabled. Explicitly disabling
+    // experimental-strip-types option seems to work around this, but long term
+    // a proper solution would be to switch our usage of ts-node (and a related
+    // load from source mocha register functionality) from relying on cjs module
+    // system to esm one (meaning we should use ts-node/esm instead of just
+    // ts-node register)
+    'no-experimental-strip-types',
+  ],
 };
diff --git a/configs/mocha-config-compass/react.js b/configs/mocha-config-compass/react.js
index e8effb04630..55d5f5d6259 100644
--- a/configs/mocha-config-compass/react.js
+++ b/configs/mocha-config-compass/react.js
@@ -12,4 +12,8 @@ module.exports = {
     path.resolve(__dirname, 'register', 'jsdom-extra-mocks-register.js'),
     path.resolve(__dirname, 'register', 'node-env-register.js'),
   ],
+  'node-option': [
+    // TODO(COMPASS-10162): see ./index.js
+    'no-experimental-strip-types',
+  ],
 };
diff --git a/package-lock.json b/package-lock.json
index 7dfa7ec7353..2dd8d58d983 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -22,7 +22,7 @@
         "node-gyp": "^10.2.0"
       },
       "engines": {
-        "node": ">=22.15.1",
+        "node": ">=22.21.1",
         "npm": ">=10.2.4"
       }
     },
diff --git a/package.json b/package.json
index c832d29992e..3b1d0eb5124 100644
--- a/package.json
+++ b/package.json
@@ -77,7 +77,7 @@
     "node-gyp": "^10.2.0"
   },
   "engines": {
-    "node": ">=22.15.1",
+    "node": ">=22.21.1",
     "npm": ">=10.2.4"
   },
   "bugs": {